Firdous Physiology Full !EXCLUSIVE!

Firdous Physiology Full !EXCLUSIVE!

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Firdous Physiology Full

The effect of LOM ablation on the electrical remodeling of the left atrium produced by pulmonary hypertension was further explored to assess the contribution of the LOM to atrial remodeling. ERP of the right atrium (RA) was taken as a standard control. The PVs were the only atrial structures whose ERP was predictably and significantly shortened by pulmonary hypertension. In this model of pulmonary hypertension, the PVs showed a decrease in ERP of approximately 50% ( Figure 4 ). Nonetheless, unlike the PVs, ablation of the LOM did not cause any significant alteration in ERP of the PVs ( Figure 4 ). As these experiments utilized an established model of pulmonary hypertension, the effect of LOM ablation on the electrical remodeling of the PVs would have been much more pronounced and could have been a more profound contribution to atrial remodeling if the LOM had been successfully targeted in other experimental models of pulmonary hypertension. In addition, as alluded to above, the effect of LOM ablation on the autonomic innervation of the PVs, which is a pivotal contributor to the development of atrial structural remodeling, needs to be further explored.

While these observations were quite interesting, the full benefits of the study still had to be realized. Therefore, to demonstrate any differences between the CH-D stellate ganglia and those of the SH-D stellate ganglia in the physiological components of the LA, a further set of VN samples were harvested and treated similarly to the SH-D stellate ganglia samples. The results were compared with a control group of vagal samples that were left unstained.



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