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The full free and complete download of Memoirs of an Imperfect Angel by Mariah Carey.Efficacy of the whole-body cryotherapy-based combination therapy for periocular basal cell carcinoma (BCC) in patients after excisional surgery for BCC.
Cryotherapy has been reported to be effective in the management of periocular BCC. However, previous studies have focused on the preoperative treatment of BCC using the combination of cryotherapy and curettage. No prospective study has evaluated the efficacy of the whole-body cryotherapy-based combination therapy with or without intralesional cryotherapy for periocular BCCs after surgery. We prospectively investigated the efficacy of the combination therapy of whole-body cryotherapy and intralesional cryotherapy for periocular BCCs after excisional surgery. All enrolled patients were treated with the combination therapy on an outpatient basis from January 1, 2009, through December 31, 2010. Of the 124 patients enrolled, 4 patients who had previously received one or more sessions of whole-body cryotherapy and intralesional cryotherapy were excluded. The remaining 120 patients (mean age = 70.8 years; 47 men, 73 women) with 110 operatively treated and 18 recurrent BCCs (mean size, 1.9 cm) were evaluated with a mean follow-up of 23.0 months. The mean number of treatment sessions was 7.9 in the periocular skin and 4.8 in the pretarsal area. The overall complete response was 92.3%, and the complete response rates in the periocular skin and pretarsal area were 75.2% and 81.8%, respectively. Recurrences were noted in 9 patients (7.5%). The Kaplan-Meier estimate of local recurrence-free survival time was 75.1% at 1 year, 51.4% at 3 years, and 45.3% at 5 years. Patients who had at least two sessions of cryotherapy had a better local tumor control than those who had one session of cryotherapy, whereas no significant difference was found between patients who had one session of cryotherapy and those who did not undergo cryotherapy at all. Our data suggest that whole-body cryotherapy-based combination therapy may be a highly effective treatment option for patients with periocular BCC.Q:
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