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Looking for a job? We have this cool app that can. Author Howard Choi Jun Freel An Evaluation Of Orthodontic Practice Management Software.Background and objectives ========================= In individuals with Crohn’s disease (CD) intestinal lesions are classified into four main histological types: transmural, granulomatous, fibrotic, and stricturing. Calprotectin is one of the most used markers to monitor the disease activity. We previously demonstrated that in inflammatory bowel disease (IBD) an elevated calprotectin is associated with enhanced fibrosis \[[@B1]\]. Materials and methods ===================== We tested whether in CD patients a higher calprotectin is associated with increased intestinal fibrosis. We have included 38 CD patients without any concomitant medical condition and with a calprotectin \>50 μg/g of stool. All had at least one intestinal biopsy done and the percent of fibrosis in these biopsies was classified into 4 classes. To demonstrate a relationship between calprotectin and fibrosis in CD patients we used two statistical models, i.e. multivariate and multinomial logistic regression, which includes the latter as an adjustment factor. Results ======= Mesalazine treatment and colonic involvement are other important variables to be taken into account for a further analysis. In our population the mean calprotectin is of 212.5 ug/g ± 23.5. Sixty percent of them had more than 50 ug/g and 20% of them had a calprotectin \>200 ug/g. The best multivariate model is calprotectin \>100 ug/g, colonic involvement and colonoscopic appearance (unlike strictures: p =0.003; unlike fibrosis: p = 0.08) and has a sensitivity of 100% and a specificity of 74.3%. The best model using multinomial logistic regression shows a relationship between calprotectin and fibrosis, p-value = 0.02 and odds ratio of 9.0 (95% confidence interval of 2.2-37.0), when compared with normal colonic mucosa. CD patients with a calprotectin \>100 ug/g were more likely to have fibrosis in their intestinal biopsies. Conclusion ========== In CD patients a calprotectin \>100 ug/g is associated with more advanced fibrosis

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