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Osteoclasts (bone cells) are destroyed with practice applications, including carbonated beverages, citrus drinks, alcoholic beverages, and sweets. Functional role: In a human, osteoblasts develop and are initially located on the exterior, nonosteoblastic part of the bone. Osteoclasts are marrow-derived cells that remove and breakdown bone. They may play an essential role in basic metabolism However, they have also been proposed to impact the brain and alter its behavior. For instance, a 2005 US study noted that male college students who drank alcohol for the first time (and were not drunk) had more behavior problems the next day. In another study, researchers in Japan found that regular drinkers were more prone to depression than abstainers. This pattern of results showed that the relationships between alcohol consumption and negative outcomes were stronger in people who were drinking proactively rather than after being drunk. Similarly, German researchers have suggested that alcohol use may be responsible for a higher prevalence of dementia. Although the biological mechanisms that underlie these relationships remain unclear, they probably involve decreases in function of the brain reward system. Osteoclast-like cells in different regions of the human brain may have different roles. One of the oldest hypotheses is that they are involved in neuronal development and physiology. This is supported by the fact that in rats, these cells have been found to have an overwhelming role in the enhancement of cognition. In 2003, some researchers speculated that this may also be the case in the human brain. This hypothesis has been partially supported by the observation that compounds known to increase bone density or reduce bone resorption (by increasing osteoblast function) increase neurogenesis and memory in rodents. For instance, the brain reward system in the brainstem, known as the mesolimbic dopamine system, becomes activated when our bodies detect natural rewards such as food and exercise, perhaps to heighten the experience of these rewards. Juriquilla batida The same system appears to work in reverse when we detect unhealthy substances such as alcohol. Rats have been found to focus more strongly on alcohol when they are given a substance that enhances the function of mesolimbic dopamine (see Dopamine system: Mesolimbic dopamine system). Consequently, mesolimbic dopamine receptor

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