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The next question is, would these booster doses be mandatory? A World Health Organization expert panel meeting held in Geneva, Switzerland in May 2020 found that booster doses would depend on the effectiveness and safety of the vaccine. The panel also cited that the risk of severe side effects is highest in the elderly and other vulnerable populations. In such a case, preventative measures would have to be taken to mitigate this risk.
The next question we need to ask is, why would it be easier to prescribe than discuss? Even in countries where booster doses are mandatory, the need for booster doses is only added to the documents of all organ transplant recipients after they have been put on the transplant waiting list. A study of 4500 organ transplant recipients conducted in Norway found, a one-time booster dose is not effective in preventing rejection or graft failure. The need for booster doses was shown to be ineffective in an earlier trial conducted in 36 patients in Germany with severe COVID-19. It’s only recommended for transplant recipients as an optional addition to their existing immunosuppressive regimes, if they require such regimes. In such cases, physicians must discuss the benefits and possible risks of administering the vaccine on an individual patient basis. It is easy to forget to do so, or to forget to add the booster dose to the patient’s documents.
If booster doses are to be administered in countries where booster doses are not mandatory, why do they need to be delivered by injection? While there are some studies underway on the effectiveness of intranasal or transcutaneous vaccines, the only approved oral vaccine is GlaxoSmithKline’s (GSK) Pluserix, which is not currently available to all countries.
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