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Altered levels of amyloid beta-42 (Aβ42) in plasma have been repeatedly reported in schizophrenia. In order to estimate plasma Aβ42 levels in schizophrenia, we performed a systematic review and meta-analysis. Six databases were searched for studies, published up to February 2013, that compared Aβ42 levels in schizophrenia patients and healthy controls. We included eight studies including 2773 schizophrenia patients and 5187 controls with a mean weighted age of 40.3 years (SD = 12.8). Plasma Aβ42 levels were significantly lower in schizophrenia patients compared to controls (OR = 0.71, 95% CI: 0.61, 0.82). In terms of subgroups, no difference was found between first episode and chronic patients (OR = 0.75, 95% CI: 0.56, 1.00) and no difference was found in antipsychotic medication (OR = 0.84, 95% CI: 0.58, 1.24). No difference was found between schizophrenia spectrum disorders and schizophrenia (OR = 0.85, 95% CI: 0.75, 0.98). Plasma Aβ42 levels are reduced in schizophrenia, regardless of the medication. This finding lends further support to the amyloid cascade hypothesis of schizophrenia.Horny shemale with big tits
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